Science played a central role in taking scattered imperial colonies in North America to world power in just four centuries. This course investigates people, policies, and knowledge-making in a culture whose diversity was a critical part of its expanding capacities. It begins by examining the differences in ways of knowing as well as shared knowledge between Native Americans and Europeans and concludes by discussing how a powerful nation's science and technology shaped international relations. Class, race, ethnicity, and gender provided for a range of perspectives that contributed to science alongside social and economic developments. Online assignments, films and images, along with primary and secondary source readings provide the basis for class discussion.